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A physiologically based pharmacokinetics model for florfenicol in crucian carp and oral‐to‐intramuscular extrapolation
Author(s) -
YANG F.,
SUN N.,
SUN Y. X.,
SHAN Q.,
ZHAO H. Y.,
ZENG D. P.,
ZENG Z. L.
Publication year - 2013
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.2012.01419.x
Subject(s) - florfenicol , crucian carp , pharmacokinetics , physiologically based pharmacokinetic modelling , pharmacology , carassius auratus , chemistry , carp , biology , antibiotics , biochemistry , fishery , fish <actinopterygii>
Yang, F., Sun, N., Sun, Y. X., Shan, Q., Zhao, H. Y., Zeng, D. P., Zeng, Z. L. A physiologically based pharmacokinetics model for florfenicol in crucian carp and oral‐to‐intramuscular extrapolation. J. vet. Pharmacol. Therap. 36 , 192–200. In this study, an oral physiologically based pharmacokinetics (PBPK) model was developed for florfenicol in crucian carp ( Carassius auratus ). Subsequently, oral‐to‐intramuscular extrapolation was performed and the two models were used to predict florfenicol concentrations in the edible tissues of crucian carp. The oral model gave good predictions in most tissues, except for kidney and liver in which the florfenicol concentrations were underestimated at the later time points. In contrast, using the intramuscular model, the concentrations in the kidney were overestimated at the later time points. Both models had the best predictive ability in the main edible tissue, the muscle. The oral model also accurately predicted the florfenicol concentrations in the muscle after multiple doses. The present study demonstrated the feasibility of predicting florfenicol concentrations in the edible tissues of crucian carp using a route‐to‐route extrapolation method.