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Pharmacokinetics of enrofloxacin in allogynogenetic silver crucian carp, Carassius auratus gibelio
Author(s) -
FANG X.,
LIU X.,
LIU W.,
LU C.
Publication year - 2012
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.2011.01337.x
Subject(s) - crucian carp , pharmacokinetics , enrofloxacin , metabolite , bioavailability , chemistry , oral administration , active metabolite , area under the curve , pharmacology , ciprofloxacin , medicine , biology , biochemistry , antibiotics , fishery , fish <actinopterygii>
Fang, X., Liu, X., Liu, W., Lu, C. Pharmacokinetics of enrofloxacin in allogynogenetic silver crucian carp, Carassius auratus gibelio . J. vet. Pharmacol. Therap. 35 , 397–401. The pharmacokinetics of enrofloxacin (EF) was investigated after single intravenous (i.v.) and oral (p.o.) administration of 10 mg/kg body weight (b.w.) in 300 healthy allogynogenetic silver crucian carp at 24–26 °C. The plasma concentrations of EF and its metabolite ciprofloxacin (CF) were determined by high‐performance liquid chromatography. After i.v. administration, the plasma concentration–time data were described by an open two‐compartment model. The elimination half‐life ( T 1/2β ), area under the concentration–time curve (AUC) and total body clearance of EF were 63.5 h, 239.6 μg·h/mL and 0.04 L/h/kg, respectively. Following p.o. administration, the plasma concentration–time data showed a double peak–shaped curve, indicating the possibility of enterohepatic recirculation of EF in allogynogenetic silver crucian carp. The maximum plasma concentration ( C max ), T 1/2β and AUC of EF were 4.5 μg/mL, 62.7 h and 205.9 μg·h/mL, respectively. Absorption of EF was very good with a bioavailability ( F ) of 86%, which could be correlated with the unique structure of the alimentary canal in allogynogenetic silver crucian. CF, an active metabolite of EF, was not detected in this study.