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Enantioselective pharmacokinetics of ketoprofen in piglets: the significance of neonatal age
Author(s) -
FOSSE T. K.,
HORSBERG T. E.,
HAGA H. A.,
HORMAZABAL V.,
RANHEIM B.
Publication year - 2011
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.2010.01205.x
Subject(s) - ketoprofen , pharmacokinetics , medicine , chemistry , anesthesia , pharmacology , zoology , biology
Fosse, T.K., Horsberg, T.E., Haga, H.A., Hormazabal, V., Ranheim, B. Enantioselective pharmacokinetics of ketoprofen in piglets: the significance of neonatal age. J. vet. Pharmacol. Therap. 34 , 153–159. Following intravenous dose of 6 mg/kg racemic ketoprofen, the chiral pharmacokinetics of ketoprofen was investigated in eight piglets aged 6 and 21 days old. S‐ketoprofen predominated over R‐ketoprofen in plasma of the piglets in both age groups. The volumes of distribution of S‐ketoprofen for the 6‐ and 21‐day‐old piglets were 241.7 (211.3–276.5) mL/kg and 155.0 (138.7–173.1) mL/kg, respectively, while the corresponding parameters for R‐ketoprofen were 289.2 (250.3–334.2) mL/kg and 193.0 (168.7–220.8) mL/kg. The clearances of R‐ketoprofen [948.4 (768.0–1171.2) mL/h/kg and 425 (319.1–566.0) mL/h/kg for the 6‐ and 21‐day‐old piglets, respectively] were significantly higher compared to the clearances of S‐ketoprofen [57.3 (46.6–70.4) mL/h/kg and 33.8 (27.0–42.2) mL/h/kg for 6‐ and 21‐day‐old piglets, respectively]. The elimination half‐life of S‐ketoprofen was 3.4 h for both age groups, while the elimination half‐life of R‐ketoprofen was 0.2 h for the 6‐day‐old and 0.4 h for the 21‐day‐old piglets. The clearances of both R‐ and S‐ketoprofen were significantly higher in the 6‐day‐old piglets compared to when they were 21 days old. Furthermore, the volumes of distribution were larger in the youngest age group.