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Pharmacokinetics of ruminally dosed sodium [ 36 Cl]chlorate in beef cattle
Author(s) -
OLIVER C. E.,
CRAIGMILL A. L.,
CATON J. S.,
ANDERSON R. C.,
SMITH D. J.
Publication year - 2007
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.2007.00870.x
Subject(s) - chlorate , sodium chlorate , chemistry , pharmacokinetics , half life , gastrointestinal tract , absorption (acoustics) , sodium , zoology , pharmacology , biochemistry , medicine , biology , inorganic chemistry , physics , organic chemistry , acoustics
The recently recognized potential of sodium chlorate as a possible preharvest food safety tool for pathogen reduction in meat animals has spurred interest in the pharmacokinetics of intraruminally dosed chlorate. Six Loala cattle were assigned (one heifer and one steer per treatment) to one of three intraruminal doses of radiolabeled sodium [ 36 Cl]chlorate (21, 42, or 63 mg/kg body weight) administered in four equal aliquots over a 24‐h period. Blood and serum were collected (29 samples in 48 h). Total radioactive residues were measured and the radioactive moieties were speciated. Chlorate appeared rapidly in blood and serum after dosing. For animals administered a dose of 42 or 63 mg/kg, the half‐life of absorption was estimated at 0.6–0.9 h. Serum chlorate concentrations progressively increased with aliquot administration until peaking at 6–21 parts per million at 26 h. Between aliquot administrations, serum chlorate levels typically peaked in 3.5 h or less. The half‐life of chlorate elimination ranged between 6.9 and 11 h, depending on the dose. Ultimately, absorption of chlorate removes it from its desired site of action, the lower gastrointestinal tract, thereby reducing its efficacy. Further research is needed to develop a chlorate formulation that will allow passage to the lower gastrointestinal tract.