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Pharmacokinetic studies on tobramycin in horses
Author(s) -
HUBENOV H.,
BAKALOV D.,
KRASTEV S.,
YANEV S.,
HARITOVA A.,
LASHEV L.
Publication year - 2007
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.2007.00860.x
Subject(s) - tobramycin , pharmacokinetics , urine , chemistry , high performance liquid chromatography , antibiotics , pharmacology , plasma concentration , chromatography , horse , medicine , gentamicin , biology , biochemistry , paleontology
The objective of the study was to evaluate the pharmacokinetics of tobramycin in plasma and urine in the horse ( n = 7) after intravenous administration of a dose of 4 mg/kg b.w. Plasma tobramycin concentrations were assayed microbiologically and by means of HPLC analyses. Pharmacokinetic parameters, calculated on the basis of concentrations determined with the microbiological assay were not statistically different from those obtained when data from HPLC analysis were used, but the microbiological assay was more sensitive in the detection of low plasma and urine values. The values of the total body clearance ( Cl B ) were 101.4 ± 30.1 and 130.0 ± 49.9 mL/kg/h, respectively. The overall extraction ratio was 2.9%. The determined capacity of elimination of tobramycin in horses was similar to those for other aminoglycosides. Within 24 h after treatment, 57.6 ± 12.2% of injected antibiotic was excreted in the urine.