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Pharmacokinetics of florfenicol, thiamphenicol, and chloramphenicol in turkeys
Author(s) -
SWITAŁA M.,
HRYNYK R.,
SMUTKIEWICZ A.,
JAWORSKI K.,
PAWLOWSKI P.,
OKONIEWSKI P.,
GRABOWSKI T.,
DEBOWY J.
Publication year - 2007
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.2007.00827.x
Subject(s) - thiamphenicol , florfenicol , pharmacokinetics , chloramphenicol , bioavailability , chemistry , antibiotics , broiler , plasma concentration , chromatography , pharmacology , zoology , oral administration , medicine , biology , food science , biochemistry
The pharmacokinetics of florfenicol (FF), thiamphenicol (TP) and chloramphenicol (CP) after single intravenous (i.v.) or oral (p.o.) administration was studied in an independent cross‐over study in broiler turkeys. All the fenicol antibiotics were administered at a dose of 30 mg/kg b.w. and their concentrations in plasma samples were assayed using the same validated high‐performance liquid chromatography method. Pharmacokinetic parameters were calculated by a noncompartmental method. The kinetic profiles of the compounds were compared with the results of the structure–activity relationship. According to the proposed mathematical description, no differences in plasma clearance values for the studied antibiotics were observed. The mean residence time values of FF, TF, and CP after i.v. injection were 3.37 ± 0.63, 2.43 ± 0.29, and 2.12 ± 0.21 h, respectively. The mean values of V area for FF (1.39 ± 0.31 L/kg) and TP (1.31 ± 0.19 L/kg) were similar, but significantly different from that of CP (1.04 ± 0.12 L/kg). The bioavailabilities of FF, TP, and CP after oral administration were 82%, 69%, and 45%, respectively. Differences in the bioavailability values of the compared fenicol antibiotics correspond to the ratio of the apolar/polar surface areas of their particles.