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Development of CALUX bioassay‐based systems as instruments to detect hormones and contaminants
Author(s) -
BROUWER A.,
SONNEVELD E.,
STERK S.,
STEPHANY R.,
VAN DER BURG B.
Publication year - 2006
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.2006.00774_3.x
Subject(s) - bioassay , veterinary drugs , biochemical engineering , contamination , pollutant , environmental chemistry , microbiology and biotechnology , environmental science , toxicology , risk analysis (engineering) , biology , chemistry , medicine , engineering , veterinary medicine , ecology
Objective Tremendous progress has been made in the ability to measure particular contaminants or veterinary drugs at very low concentrations. However, rare or previously unknown compounds, metabolites and mixtures are still presenting considerable analytical challenges, while this category in particular might be relevant in terms of food safety. In addition, the need for higher throughput screening strategies at lower costs also demands for methods in addition to chemical analysis. There is considerable development in methodology based on the interaction with bio‐macromolecules or living cells or on a biological response in the exposed animal. The aim of this workshop is to provide an up‐o‐date and practical overview of the various analytical and biological strategies that are available to screen or detect (prior) exposure to drugs, contaminants and pollutants.