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Pharmacokinetics of levamisole in broiler breeder chickens
Author(s) -
ELKHOLY H.,
KEMPPAINEN B.,
RAVIS W.,
HOERR F.
Publication year - 2006
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.2006.00710.x
Subject(s) - levamisole , pharmacokinetics , broiler , zoology , breed , breeder (animal) , high performance liquid chromatography , volume of distribution , chemistry , veterinary medicine , biology , pharmacology , medicine , chromatography , immunology , materials science , composite material , blanket
The pharmacokinetics of levamisole was studied in 20 broiler breeder chickens (chickens that give eggs to breed broilers). A single dose of levamisole (40 mg/kg) was administered orally or intravenously to chickens before the onset of egg production, prelay (age = 22 weeks), and repeated at the peak of egg production (age = 32 weeks). A high‐pressure liquid chromatographic with ultraviolet detection method (HPLC‐UV) was used for quantification of levamisole in plasma. Using compartmental analysis, levamisole followed a three‐compartmental open model with mean values of α = 0.1224 and 0.4968, β = 0.01663 and 0.01813, γ = 0.002 and 0.002/min at the prelay and at the peak of egg production periods, respectively. The mean values for volume of distribution at steady state ( V ss ), determined by compartmental analysis, were significantly different for prelay and peak of egg production (8.358 and 13.581 mL/kg), respectively.