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Application of risk assessment and management principles to the extralabel use of drugs in food‐producing animals
Author(s) -
GEHRING R.,
BAYNES R. E.,
RIVIERE J. E.
Publication year - 2006
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.2006.00707.x
Subject(s) - risk analysis (engineering) , risk assessment , human health , risk management , veterinary drugs , food safety , veterinary drug , business , food products , medicine , drug , microbiology and biotechnology , environmental health , pharmacology , veterinary medicine , computer science , biology , pathology , food science , chemistry , computer security , finance , chromatography
A risk assessment of the food safety implications of drugs used in food‐producing animals is an essential component of the regulatory approval process for products containing these drugs. This ensures that there is negligible risk to human health if these drugs are used according to the instructions that appear on the approved label. A relative paucity of approved products for veterinary species; however, forces veterinarians worldwide to use drugs in an extralabel manner to treat disease and alleviate suffering in animals. In food‐producing animals, this may result in residues that are potentially harmful to the human consumer. This review describes how risk assessment principles can be extended to evaluate the risks posed by different classes of extralabel drug use. Risk management practices in the United States and Europe are summarized and contrasted to illustrate the application of these principles.