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Pharmacokinetics and oral bioavailability of pentoxyfylline in broiler chickens
Author(s) -
DE BOEVER S.,
BAERT K.,
DE BACKER P.,
CROUBELS S.
Publication year - 2005
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.2005.00695.x
Subject(s) - bioavailability , pharmacokinetics , oral administration , metabolite , volume of distribution , plasma concentration , chemistry , broiler , pharmacology , dosing , oral dose , chromatography , medicine , biochemistry , food science
The pharmacokinetic properties of pentoxyfylline and its metabolites were determined in healthy chickens after single intravenous and oral dosage of 100 mg/kg pentoxyfylline. Plasma concentrations of pentoxyfylline and its metabolites were determined by a validated high‐performance liquid chromatographic method. After intravenous (i.v.) and oral (p.o.) administration, the plasma concentration–time curves were best described by a one‐compartment open model. The mean elimination half‐life ( t 1/2(el) ) of pentoxyfylline was 1.05 h, total body clearance 1.90 L/h·kg, volume of distribution 2.40 L/kg and the mean residence time was 2.73 h, after i.v. administration. After oral dosing, mean maximal plasma concentration of pentoxyfylline was 4.01 μ g/mL and the interval from p.o. administration until maximum concentration was 1.15 h. The mean oral bioavailability was found to be 28.2%. Metabolites I, IV and V were present in chicken plasma after both i.v. and p.o. administration, with metabolite V being the most dominant.