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Pharmacokinetics of cefepime administered by i.v. and i.m. routes to ewes
Author(s) -
ISMAIL M.
Publication year - 2005
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.2005.00689.x
Subject(s) - cefepime , pharmacokinetics , volume of distribution , bioavailability , half life , absorption (acoustics) , chemistry , pharmacology , plasma concentration , drug administration , cmax , distribution (mathematics) , urine , medicine , antibiotics , mathematics , biochemistry , antibiotic resistance , physics , acoustics , mathematical analysis , imipenem
The pharmacokinetics of cefepime were studied following i.v. and i.m. administration of 20 mg/kg in 10 ewes. Following i.v. administration of a single dose, the plasma concentration–time curves of cefepime were best fitted using a two‐compartment open model. The elimination half‐life ( t 1/2 β ) was 1.76 ± 0.07 h, volume of distribution at steady‐state [ V d(ss) ] was 0.32 ± 0.01 L/kg and total body clearance ( Cl B ) was 2.37 ± 0.05 mL/min·kg. Following i.m. administration, the drug was rapidly absorbed with an absorption half‐life ( t 1/2ab ) of 0.49 ± 0.05 h, maximum plasma concentration ( C max ) of 31.9 ± 1.5 μ g/mL was attained at ( t max ) 1.1 ± 0.2 h and the drug was eliminated with an elimination half‐life ( t 1/2el ) of 2.06 ± 0.11 h. The systemic bioavailability ( F ) after i.m. administration of cefepime was 86.8 ± 7.5%. The extent of plasma protein binding measured in vitro was 14.8 ± 0.54%. The drug was detected in urine for 36 h postadministration by both routes.