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Pharmacokinetics of levofloxacin after single intravenous and repeat oral administration to cats
Author(s) -
ALBARELLOS G. A.,
AMBROS L. A.,
LANDONI M. F.
Publication year - 2005
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.2005.00669.x
Subject(s) - levofloxacin , pharmacokinetics , bioavailability , volume of distribution , oral administration , medicine , pharmacology , dosing , minimum inhibitory concentration , absorption (acoustics) , antibiotics , chemistry , biochemistry , physics , acoustics
The pharmacokinetic properties of the fluoroquinolone levofloxacin, were investigated in five cats after single intravenous and repeat oral administration at a daily dose of 10 mg/kg. Levofloxacin serum concentration was analyzed by microbiological assay using Klebsiella pneumoniae ATCC 10031 as test microorganism. Serum levofloxacin disposition after intravenous and oral dosing was best fitted to a bicompartmental and a monocompartmental open models with first‐order elimination, respectively. After intravenous administration, distribution was rapid ( t 1/2(d) 0.26 ± 0.18 h) and wide as reflected by the steady‐state volume of distribution of 1.75 ± 0.42 L/kg. Drug elimination was slow with a total body clearance of 0.14 ± 0.04 L/h·kg and a t 1/2 for this process of 9.31 ± 1.63 h. The mean residence time was of 12.99 ± 2.12 h. After repeat oral administration, absorption half‐life was of 0.18 ± 0.12 h and T max of 1.62 ± 0.84 h. The bioavailability was high (86.27 ± 43.73%) with a peak plasma concentration at the steady state of 4.70 ± 0.91 μ g/mL. Drug accumulation was not significant after four oral administrations. Estimated efficacy predictors for levofloxacin after either intravenous or oral administration indicate a good profile against bacteria with a MIC value below of 0.5 μ g/mL. However, for microorganisms with MIC values of 1 μ g/mL it would be efficacious only when administered intravenously.