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Clinical efficacy of carprofen as an adjunct to the antibacterial treatment of bovine respiratory disease
Author(s) -
Elitok B.,
Elitok Ö. M.
Publication year - 2004
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.2004.00589.x
Subject(s) - tilmicosin , medicine , dosing , pneumonia , clinical disease , clinical trial , pharmacology , disease , antibiotics , biology , microbiology and biotechnology
A clinical trial was undertaken to investigate the efficacy of a single dose of carprofen (CPF) in the treatment of bovine respiratory disease in cattle. Tilmicosin was used as a basal treatment in all animals. Six hours after dosing, body temperature and respiratory rates in animals treated with CPF–tilmicosin had decreased and were significantly lower than in the animals treated with tilmicosin alone ( P < 0.05). Over the period of clinical observation, CPF–tilmicosin treatment produced a clinical resolution of the pneumonia similar to treatment with tilmicosin alone. However, it is significant from an animal welfare perspective that over the period of the study after treatment, CPF–tilmicosin therapy produced significantly greater symptomatic improvement than tilmicosin.