Premium
Age‐related changes in the pharmacokinetics of marbofloxacin after intravenous administration in goats
Author(s) -
Waxman S.,
San Andrés M. D.,
González F.,
San Andrés M. I.,
De Lucas J. J.,
Rodríguez C.
Publication year - 2004
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.2004.00548.x
Subject(s) - pharmacokinetics , volume of distribution , zoology , body weight , high performance liquid chromatography , plasma clearance , medicine , chemistry , biology , chromatography
The pharmacokinetics of marbofloxacin was studied in adult goats and 1‐, 3‐ and 6‐weeks‐old kids after single dose i.v. dose of 2 mg/kg body weight. Drug concentration in plasma was determined by high‐performance liquid chromatography (HPLC) and the data collected were subjected to compartmental kinetic analysis. Volume of distribution was relatively high in adult goats ( V ss = 1.31 L/kg), and increased with age ( V ss = 0.92 L/kg, 0.95 L/kg and 1.00 L/kg, in 1‐, 3‐ and 6‐weeks‐old kids respectively). Total body clearance ( Cl ) also increased with age from 0.080 L/kg·h (1‐week‐old) to 0.097 L/kg·h (3‐weeks‐old), 0.18 L/kg·h (6‐weeks‐old) and 0.23 L/kg·h (adult goats). As a consequence of increased body Cl , area under the plasma concentration vs. time curve decreased with age ( AUC = 27.46 μ g·h/mL, 22.61 μ g·h/mL, 11.86 μ g·h/mL and 8.44 μ g·h/mL in 1‐, 3‐, 6‐weeks‐old kids and adults, respectively) and a longer elimination half‐life was found during the first 3 weeks of age ( t 1/2 β = 9.66 h, 8.25 h, 6.44 h and 7.18 h, in 1‐, 3‐, 6‐weeks‐old kids and adults, respectively). Mean residence time decreased with age from 11.86 h in 1‐week‐old kids to 9.63 h (3 weeks), 5.76 h (6 weeks) and 5.06 h in adult goats.