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Lack of local anaesthetic efficacy of Sarapin® in the abaxial sesamoid block model
Author(s) -
HARKINS J. D.,
MUNDY G. D.,
STANLEY S. D.,
SAMS R. A.,
TOBIN T.
Publication year - 1997
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1997.tb00100.x
Subject(s) - local anaesthetic , analgesic , anesthesia , medicine , reflex , hoof , horse , biology , anatomy , paleontology
Sarapin® is a distillate of the pitcher plant that has long been used in human and veterinary medicine for‘regional analgesia’. The mechanism of the reported analgesic response is unknown; however, the agent is purported to provide more effective analgesia for slow, chronic pain than for sharp, acute pain. Reportedly, Sarapin® is also widely used as an analgesic agent in the horse, generally in combination with corticosteroids and other agents. To determine its local anaesthetic efficacy in the horse, we tested Sarapin® in a unilateral abaxial sesamoid block model at two dose levels, 2 mL and 10 mL per site, respectively. Cutaneous pain was induced with a light/heat lamp, and analgesia was assessed by measuring the hoof‐withdrawal reflex latency period. Neither dose of Sarapin® altered hoof‐withdrawal reflex latency in this experimental model tested over a two‐week period. Based on the demonstrated efficacy of this local anaesthetic model, it seems clear that Sarapin® has no significant classical local anaesthetic actions in the horse, and probably not in other species either.