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Pharmacokinetic study of dipyrone metabolite 4‐MAA in the horse and possible implications for doping control
Author(s) -
KLAUS ANAMARIA,
SCHLINGLOFF Y.,
KLEINITZ U.,
BÖTTCHER M.,
HAPKE H.J.
Publication year - 1997
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1997.tb00096.x
Subject(s) - metabolite , horse , pharmacokinetics , pharmacology , active metabolite , chemistry , medicine , biology , paleontology
The pharmacokinetic behaviour of dipyrone metabolite 4‐MAA in serum was determined in seven horses of different breeds after a single intravenous dose administration. A biexponential formula was fitted to the serum concentration vs. time data. The median half‐life of the elimination phase ( t 1/2β ) was 4.85 h (range 5.04 h), the median volume of distribution ( V d area ) was 1.85 L/kg (range 3.2 L/kg) and median of total clearance was 4.0 mL/min/kg (range 2.3 mL/min/kg).