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Bioavailability of ketoprofen in horses after rectal administration
Author(s) -
CORVELEYN S.,
DEPREZ P.,
WEKEN G. VAN DER,
BAEYENS W.,
REMON J. P.
Publication year - 1996
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1996.tb00064.x
Subject(s) - suppository , ketoprofen , rectal administration , bioavailability , volume of distribution , pharmacokinetics , medicine , rectal temperature , anesthesia , pharmacology
Six healthy mares ranging in age from 6 to 12 years and weighing from 415 to 540 kg were used to determine the rectal bioavailability of ketoprofen. For the rectal administration, three different formulations, each containing 1 g of ketoprofen, were administered in a fatty and a hydrophilic suppository base and as a liquid suspension. An average elimination half‐life of 1.3 h (±1.2) was found. The average value for the total plasma clearance ( Cl T ) was 131.9 mL/min.kg (range 95‐183.5). The volume of distribution V d(area) was 255 mL/kg and the mean residence time (MRT)P = 0.05; Friedman test). Despite the low rectal bioavailability obtained in this study, there was some evidence for the clinical effectiveness of the rectal formulations.