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Bioavailability and pharmacokinetics of ibuprofen in the broiler chicken
Author(s) -
RODER J. D.,
CHEN C. L.,
CHEN H.,
SANGIAH S.
Publication year - 1996
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1996.tb00039.x
Subject(s) - broiler , bioavailability , pharmacokinetics , ibuprofen , pharmacology , chemistry , food science , medicine
The intravenous, intramuscular and oral pharmacokinetics of ibuprofen in broiler chickens were investigated. In a preliminary study, plasma ibuprofen concentration‐time profiles, following i.v. (25 mg/kg) dosing were best described by a 2‐compartment model. After intravenous administration, the volume of distribution at steady‐state ( V d(ss) ), the total systemic clearance ( Cl B ), the elimination half‐life (t 1/2p ) and the MRT were 0.303 L/kg, 482.3 ml/h‐kg, 2.71 h and 1.02 h, respectively. After intramuscular administration of ibuprofen, the t max and C max were 0.37 h, and 42.2μg/mL, respectively, with an estimated bioavailability of 46.7%. After oral administration of ibuprofen, the t max and C max were 0.31 h and 23.91 μg/mL, respectively, with an estimated bioavailability of 24.2%. This is a preliminary study, examining the use of ibuprofen in broiler chickens, and should be followed by tissue residue and efficacy studies in different disease states.