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Single dose pharmacokinetics of medetomidine in sheep
Author(s) -
MUGE D. K.,
CHAMBERS J. P.,
LIVINGSTON A.
Publication year - 1996
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1996.tb00021.x
Subject(s) - medetomidine , pharmacokinetics , volume of distribution , chemistry , distribution volume , distribution (mathematics) , pharmacology , chromatography , medicine , heart rate , mathematics , blood pressure , mathematical analysis
The pharmacokinetics of medetomidine hydrochloride (Domitor) administered at a single dose of 15 μg/kg IV in sheep are described. Plasma medetomidine concentrations were determined using a sensitive radioreceptor assay technique, capable of also measuring metabolites which would bind to α 2 adrenergic receptors. Medetomidine was rapidly distributed, with a half‐life of distribution of 4.65/pm0.65 min. The apparent volume of distribution was 2.69/pm0.62 L/kg, while elimination half‐life was 37.85/pm2.84 min. Total body clearance varied between 16.29 and 151.81 mL/min.kg. Pharmacological effects of medetomidine paralleled its plasma concentration.