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The pharmacokinetics of salicylate in dairy cattle are not altered by simultaneous intravenous ceftiofur sodium and DL‐lysine‐acetyl salicylate (Aspirin)
Author(s) -
WHITTEM T.,
FREEMAN D. A.,
PARTON K.,
HANLON D. W.
Publication year - 1996
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1996.tb00020.x
Subject(s) - ceftiofur , sodium salicylate , pharmacokinetics , aspirin , chemistry , zoology , pharmacology , volume of distribution , sodium , medicine , chromatography , antibiotics , biochemistry , biology , cephalosporin , organic chemistry
This study evaluated potential alterations to the pharmacokinetics of salicylate by concurrently administered ceftiofur sodium. The trial design was a crossover using 10 non‐lactating, non‐pregnant dairy cows. In the first period each cow received intravenously (IV) 26 mg/kg of DL‐lysine acetyl salicylate (aspirin) followed immediately by 2 mg/kg ceftiofur sodium. In the second period each cow received 26 mg/kg of aspirin IV. Plasma samples were harvested for determination of salicylate concentration by HPLC. The data best fitted a single compartment open model, using weighted non‐linear regression. No alterations to the pharmacokinetic parameters of salicylate in cattle by concurrently administered ceftiofur sodium were detected ( P <0.05). Using 90% confidence intervals, and testing for changes of > 20%. control values, elimination half‐life ( t 1 / 2 ), apparent volume of distribution ( V d ), area under the plasma concentration versus time curve ( AUC ) and mean residence time ( MRT ) were not altered. For control animals the elimination rate constant ( k el ) and total body clearance ( Cl ) were 1.35/pm0.43 h −1 and 20.2/pm6.1 ml/h.kg respectively (mean/pmSD). Since ceftiofur sodium did not affect the pharmacokinetics of salicylate, dose regimens for aspirin in cattle need not be altered when ceftiofur sodium is administered concurrently.