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Chirality: a major issue in veterinary pharmacology
Author(s) -
LANDONI M. F.,
LEES P.
Publication year - 1996
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1996.tb00015.x
Subject(s) - enantiomer , pharmacodynamics , pharmacology , pharmacokinetics , chirality (physics) , animal species , drug , animal model , computational biology , chemistry , medicine , biology , stereochemistry , zoology , nambu–jona lasinio model , chiral symmetry breaking , physics , quantum mechanics , quark
The sole purpose of this comment is to draw attention to the significance of enantiomorphism in the interpretation of pharmacokinetic/pharmacodynamic studies of drugs that are present in dosage forms as racemates. The proportion of the enantiomers formed from a racemate can vary in different animal species, and both the pharmacokinetic behaviour and pharmacodynamic activity can differ between the enantiomers. As a consequence, the pharmacological effects produced by a racemic drug represent the combined effects of the enantiomers formed in the particular species of animal. Enantiomorphism has a major influence on the prediction of dosage regimens for different animal species.