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Pharmacokinetics of cefoperazone in horses
Author(s) -
SORACI A. L.,
MESTORINO O. N.,
ERRECALDE J. O.
Publication year - 1996
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1996.tb00006.x
Subject(s) - pharmacokinetics , volume of distribution , bioavailability , cefoperazone , synovial fluid , absorption (acoustics) , chemistry , urine , distribution (mathematics) , oral administration , serum concentration , pharmacology , medicine , antibiotics , pathology , biochemistry , osteoarthritis , mathematical analysis , physics , alternative medicine , mathematics , antibiotic resistance , imipenem , acoustics
The pharmacokinetics and bioavailabilty of cefoperazone (CPZ) were studied following intravenous (IV) and intramuscular (IM) administration of single doses (30 mg/kg) to horses. Concentrations in serum, urine and synovial fluid samples were measured following IV administration. CPZ concentrations in serum, synovial fluid and spongy bone samples were measured following IM administration. After IV administration a rapid distribution phase ( t 1/2(α) :4.22 ± 2.73 min) was followed by a slower elimination phase ( t 1/2(β) 0.77 ± 0.19 h). The apparent volume of distribution was 0.68 ± 0.10 L/kg. Mean synovial fluid peak concentration was 5.76 ± 0.74 μg/mL. After IM administration a bioavailability of 42.00±5.33% was obtained. Half‐life of absorption was 2.51 ± 0.72 min and t 1/2(β) was 1.52±0.15 h. The mean synovial fluid and spongy bone peak concentrations at 2 h after IM administration were 2.91±0.85 μg/mL and 5.56±0.70 μg/mL, respectively.