Premium
Kinetic disposition of triclabendazole in buffalo compared to cattle
Author(s) -
SANYAL P.K.
Publication year - 1995
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1995.tb00606.x
Subject(s) - triclabendazole , bioavailability , metabolite , zoology , pharmacokinetics , plasma concentration , body weight , chemistry , veterinary medicine , biology , pharmacology , medicine , fasciola hepatica , endocrinology , biochemistry , helminths
Concentrations of triclabendazole sulfoxide and its sulfone metabolite in plasma were measured in buffalo and cross‐bred cattle after single intraruminal administration of triclabendazole at two different doses. Plasma concentrations of both metabolites were significantly lower in buffalo than cattle at both doses, which resulted in a smaller area under the concentration‐time curve, a lower concentration maximum and a lower relative bioavailability. Thus, the recommended doses of 12 mg/kg body weight for the treatment of bubaline fascloliasis may not be valid for buffalo because of the substantially lower uptake of the drug in this species.