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Disposition kinetics of tylosin tartrate administered intravenously and intramuscularly to normal and water‐deprived camels
Author(s) -
ZIV G.,
CREVELD C.V.,
BENZVI Z.,
GLICKMAN A.,
YAGIL R.
Publication year - 1995
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1995.tb00594.x
Subject(s) - tylosin , volume of distribution , pharmacokinetics , zoology , pharmacology , chemistry , dosing , physiology , antibiotics , medicine , biology , biochemistry
The disposition kinetics of tylosin tartrate administered intravenously (i.v.) at 10 mg/kg and intramuscularly (i.m.) at 20 mg/kg were studied in normal camels and in the same camels at the end of a 14 day water‐deprivation period. After i.v. treatment, serum tylosin concentrations in the water‐deprived camels were significantly higher, rate of drug elimination was slower, the volume of distribution was significantly smaller, and total body clearance was significantly slower than in the normal camels. On the other hand, serum drug concentrations were lower in the water deprived camels after i.m. dosing, the mean absorption time was significantly shorter and the i.m. availability was significantly smaller than in the normal camels. Water‐deprivation was thought to cause reduced rate of tylosin elimination by the liver, as was shown for antipyrine—a drug which is eliminated from the body exclusively by the liver. Redistribution of tylosin in tissues concomitant with a greater proportion of drug in blood and extracellular fluid of water‐deprived camels was suggested as a partial explanation for the higher serum drug levels seen after i.v. dosing. The low i.m. availability observed in the water‐deprived camels implies that i.v. is the route of choice for tylosin administration to ill, dehydrated camels.