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Disposition of ciprofloxacin following intravenous administration in dogs
Author(s) -
ABADÍA A. R.,
ARAMAYONA J. J.,
MUÑOZ M. J.,
DELFINA J. M. PLA,
SAEZ M P,
BREGANTE M A
Publication year - 1994
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1994.tb00264.x
Subject(s) - disposition , ciprofloxacin , administration (probate law) , pharmacology , medicine , antibiotics , biology , microbiology and biotechnology , psychology , law , political science , social psychology
The pharmacokinetics of ciprofloxacin (CIP) following intravenous administration m dogs nave been mvestisated. The drug was administered at three doses (2.5,5 and 10 mg/kg body weight) and was assayed in biological fluid samples (plasma and urine) by an HPLC method. The plasma concentration‐time curves ere best described by a two‐compartment open pharmacokinetic model. The was widely distributed (V d(area) almost 3 1/kg), being distributed in the dog more rapidly than in other species (t 1/2(λ1) 3 min approximately). The elimination half‐life (t 1/2λ2) ) was 129–180 min which is similar to values obtaine in other species. The unchanged drug eliminated in urine was less than 37% of the administered dose, which is less than the values obtained in humans, calves and pigs. The glomerular filtration rate and the renal clearance of CIP in the dog suggest that renal elimination probably occurs mainly by glomerular filtration. The results showed that the pharmacokinetics of CIP, as in other species, was linear in dogs in the dose range studied.