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In vitro effects of tachykinins on the smooth musculature of horse gut
Author(s) -
BELLOLI C.,
ARIOLI F.,
BERETTA C.,
MADONNA M.
Publication year - 1994
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1994.tb00263.x
Subject(s) - eledoisin , duodenum , ileum , neurokinin a , small intestine , neurokinin b , medicine , jejunum , substance p , receptor , motility , endocrinology , biology , anatomy , microbiology and biotechnology , neuropeptide
The contractile effects of the tachykinins eledoisin, substance P and neurokinin A and B were investigated in vitro on circular and longitudinal muscle strips from horse duodenum, ileum and colon. Circular smooth muscle of the small intestine was highly responsive, large intestine circular smooth muscle less so, while longitudinal muscle from all gut segments was much less sensitive. pD 2 values and intrinsic activities on small intestine circular muscle indicated differences in receptor distribution between the duodenum and ileum: NK 3 and a smaller number of NK 2 receptors being present in the duodenum, and NK 2 receptors predominating in the ileum. Notwithstanding this, eledoisin and neurokinin B were the most active substances on duodenum and ileum, respectively. These findings suggest that tachykinins may play a role in equine gastrointestinal pathophysiology.