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Pharmacokinetics of gentamicin following single dose intravenous administration in normal and febrile goats
Author(s) -
AHMAD A. H.,
BAHGA H S,
SHARMA L. D.“
Publication year - 1994
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1994.tb00261.x
Subject(s) - gentamicin , pharmacokinetics , volume of distribution , medicine , microgram , antibiotics , distribution (mathematics) , anesthesia , pharmacology , gastroenterology , chemistry , biology , microbiology and biotechnology , mathematical analysis , biochemistry , mathematics , in vitro
A pharmacokinetic study of gentamicin (5 mg/kg intravenous (i.v.)) was conducted first in cinically healthy female goats and then in the same goats after induction of fever by Escherichia coli endotoxin (0.2 μg/kg i.v.). Rectal temperature increased 1 to 1.5°C in febrile goats. Differences in the blood serum concentrations of gentamicin were not observed at any time between febrile and normal goats. The disposition kinetics of gentamicin were described by a biex‐ponential expression C P = Ae ‐αt + Be ‐β . Median values for the half‐lives of gentamicin were 103.6 min in normal and 136.0 min in febrile goats. The apparent volume of distribution (V d ) was 263.3 ml/kg in the febrile goats which was not different from that in the normal goats (240.6 ml/kg). The volume of the central compartment (V c ) was almost identical in normal and febrile goats. The body clearance (Cl β ) was observed to be 1.7 and 1.6 ml/min‐kg in normal and febrile goats, respectively. Dosage regimens for gentamicin were calculated on the basis of median kinetic data.