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Disposition of human drug preparations in the horse. III. Orally administered alclofenac
Author(s) -
DELBEKE F. T.,
LANDUYT J.,
DEBACKERE M.
Publication year - 1994
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1994.tb00258.x
Subject(s) - urine , horse , chemistry , pharmacokinetics , oral administration , oral dose , plasma concentration , pharmacology , chromatography , disposition , dosing , drug , medicine , biology , biochemistry , psychology , paleontology , social psychology , organic chemistry
Concentrations of the non‐steroidal anti‐inflammatory drug (NSAID) alclofenac were determined by a sensitive high performance liquid chromatographic procedure in plasma and urine of horses following oral administration of a dose of 3 g. In plasma, alclofenac was present in detectable concentrations for 72 h. The plasma disposition in individual horses was best described by a bi‐compartmental model with two successive rate constants ka 1 = 0.05 ± 0.06 h ‐1 and ka 2 = 0.06 ± 0.01 h ‐l . Alclofenac half‐lives t ½ and t 1/2β were 1.0 ± 0.8 h and 6.9 ± 1.5 h, respectively. Maximal concentrations (38.9 ± 16.2 μg/ml) were obtained after 8.5 ± 2.4 h. Alclofenac was detected in urine for at least 48 h after dosing. The percentage of the dose excreted as unchanged alclofenac in 12 h was very low (0.68 ± 0.19%), total (free + conjugated) alclofenac accounted for 2.16 ± 0.55% of the dose.