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Comparative study of the action of flunixin meglumine and tolfenamic acid on prostaglandin E 2 synthesis in bovine inflammatory exudate
Author(s) -
ESPINASSE J.,
THOUVENOT J. P.,
DALLE S.,
GARCIA J.,
SCHELCHER F.,
SALAT O.,
VALARCHER J. F.,
DAVAL S.
Publication year - 1994
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1994.tb00244.x
Subject(s) - carrageenan , exudate , chemistry , pharmacology , prostaglandin , prostaglandin e2 , prostaglandin e , radioimmunoassay , subcutaneous injection , biochemistry , medicine , endocrinology , pathology
An acute non‐immune inflammation model was used to compare the action of two non‐steroidal anti‐inflammatory drugs, flunixin meglumine and tolfenamic acid, on prostaglandin E 2 , (PGE 2 ) synthesis in bovine inflammatory exudate. The tissue cage model used involves subcutaneous implantation of polypropylene cages and subsequent stimulation by carrageenan injection of the granulation tissue which develops within the cage. Twelve calves were randomly assigned to three groups receiving placebo, flunixin meglumine and tolfenamic acid, respectively. Inflammatory exudate was sampled 30 min after carrageenan injection and at seven subsequent time points. PGE 2 , levels were determined by radioimmunoassay. At each time point post‐carrageenan injection, flunixin meglumine inhibited PGE 2 , synthesis to a greater extent than tolfenamic acid. At 4, 8,12 and 24 h these differences were statistically significant.