Premium
Pharmacokinetics of florfenicol following intravenous and intramuscular doses to cattle
Author(s) -
LOBELL R. D.,
VARMA K. J.,
JOHNSON J C,
Sams R. A.,
GERKEN D. F.,
ASHCRAFT S. M.
Publication year - 1994
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1994.tb00241.x
Subject(s) - florfenicol , pharmacokinetics , volume of distribution , intramuscular injection , chemistry , pharmacology , chromatography , anesthesia , medicine , antibiotics , biochemistry
The disposition of florfenicol after single intravenous and intramuscular doses of 20 mg of florfenicol/kg of body weight (b.w.) to feeder calves was investigated. Serum florfenicol concentrations were determined by a sensitive high performance liquid chromatographic method with a limit of quantitation of 0.025 μg/ml. The extent of serum protein binding of florfenicol was only 13.2% at a serum florfenicol concentration of 3.0 μg/ml. Serum concentration‐time data after intravenous administration were best described by a triexponential equation. Total body clearance and steady state volume of distribution were 3.75 ml/min/kg b.w. and 761 ml/kg b.w., respectively. The terminal half‐life after intravenous administration was 159 min. The absolute systemic availability after intramuscular administration was 78.5% (range: 59.3–106%) and the harmonic mean of the terminal half‐life was 1098 minutes, indicating slow release of the florfenicol from the formulation at the intramuscular injection site.