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Urinary excretion of metals during treatment with D‐penicillamine and 2‐mercaptopropionylglycine in normal and cystinuric dogs
Author(s) -
HOPPE A.,
DENNEBERG T.,
FRANK A.,
KÅGEDAL B.,
PETERSSON L. R.
Publication year - 1993
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1993.tb00294.x
Subject(s) - excretion , urine , chemistry , penicillamine , urinary system , medicine , endocrinology , renal physiology , renal function
Urinary excretion of nietals during treatment with 2‐rnercaptopropioiiylglycine (2‐MPG) was studied in 11 normal and 20 cystinuric male dogs. 'Ihe results were compared with those obtained during D‐penicillamine treatment. Twenty‐four‐h urine and morning samples of urine were taken for determina‐ tion of 13 metals before and during treatment. After single intravenous and oral D‐penicillamine treatment of the normal dogs, significant increases were found in the 24‐11 urinary excretion of Ca, Cu and Zn. Oral intake of D‐penicillamine increased the excretion of Ch, Cr, Fe and Mg as well. No effect on renal metal excretion was observed after single intravenous and up to 2 months of daily oral treatment with 2‐MPG. In 14 cystinuric dogs no effect was found after single intravenous and oral administrations of 2‐MPG. However, after oral treatment of six cystinuric dogs with 2‐MPG for 2–4 months, significantly increased excretions of Ca and Mg were found. Fourteen of the cystinuric dogs were also investigated after 2–6 years of continuous 2‐MPG treatment, and after this period no significant elevation in the urinary excretion of metals was found. The present study shows that in contrast to D‐penicillamine, 2‐MPG does not increase the urinary excretion of metals to any appreciable extent. Observed increases in the excretion of Ca and Mg seemed to be a temporary effect only.