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Pharmacodynamics, pharmacokinetics and faecal persistence of morantel in cattle and goats
Author(s) -
McKELLAR Q. A.,
SCOTT E. W.,
BAXTER P.,
ANDERSON L. A.,
BAIRDEN K.
Publication year - 1993
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1993.tb00293.x
Subject(s) - ostertagia ostertagi , feces , biology , zoology , veterinary medicine , fecundity , pharmacokinetics , ostertagia , pharmacodynamics , persistence (discontinuity) , trichuris , nematode , microbiology and biotechnology , pharmacology , medicine , population , ecology , environmental health , geotechnical engineering , engineering
Morantel could not be detected (<0.05 pg/ml)in the plasma of cattle or goats followingthe oral administration of morantel tartrate at a dose rate of 10 mg/kg bodyweight. No morantel was detected in the milk of lactating goats except in one animal where a concentration of 0.092 pg/ml was detected at 8 h after drug administration. Morantel was highly effective against Cooperia oncophora infec‐ tions in calves treated 6, 9 or 18 days after infection; however, was highly effective against Ostertagia ostertagi only when treated 18 days after infection. Morantel did not affect the fecundity of adult 0.ostertagi surviving treatment 18 days after infection which had similar average numbers of eggs in their uteri (range 13.4 f 0.73‐16.8 L 0.98) as did parasites from control animals (range 12.0 k 0.70‐13.6 2 0.66). Morantel could be detected at a concentration of 96 k 4.5 pgig (dry weight) in the faeces of a calf 24 h after treatment with I0 mgikg bodyweight of morantel tartrate. The concentration of morantel in replicate samples of this faeces exposed to natural atmosphere, but not to soil or soil organisms, declined slowly over the following 322 days. At day 322 after the start of the experiment 8.8 pg/g of morantel could be measured in the remaining faecal material. Throughout the faecal degradation study the concentration of morantel in the crusts of the replicate sample pats was lower than the concentration in the core samples.

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