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Lidocaine decay and hepatic extraction in the Pig
Author(s) -
METS B.,
ALLIN R.,
DYKE J. VAN,
HICKMAN R.
Publication year - 1993
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1993.tb00283.x
Subject(s) - lidocaine , pharmacokinetics , extraction (chemistry) , anesthesia , extraction ratio , laparotomy , blood flow , blood sampling , lidocaine hydrochloride , chemistry , venous blood , medicine , chromatography , pharmacology , surgery
Plasma lidocaine decay after injection was studied in five anaesthetized pigs and fitted to a two compartment open model. Derived pharniacokinetic paranieter‐s were eniployed to rapidly achieve plateau concentrations within 60 min of starting a two stage infusion of lidocaine hydrochloride. Hepatic extraction and clearance of lidocaine at steady state were determined in 10 pigs by transhep;ttic: sampling and nieasurenient of hepatic arterial and portal venous blood flow using perivascular ultrasonic flow probes placed at laparotomy. These data were compared with siniilar studies performed in man as well as the sheep, (log, monkey and cat. The lidocaine extraction ratio of 0.60 in the pig was found t o be similar to that determined by others in man.