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The effects of halothane and nitrous oxide on the pharmacokinetics of propofol in dogs
Author(s) -
NOLAN A. M.,
REID J.,
GRANT S.
Publication year - 1993
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1993.tb00180.x
Subject(s) - propofol , pharmacokinetics , nitrous oxide , anesthesia , halothane , volume of distribution , medicine , bolus (digestion) , pharmacology , surgery
The pharmacokinetics of propofol, 6.5 mg/kg, administered as a bolus dose intravenously (i.v.) were studied in six dogs (group 1). The effect of maintaining anaesthesia with halothane and nitrous oxide in oxygen on propofol pharmacokinetics was also investigated in six dogs undergoing routine anaesthesia (group 2). Induction of anaesthesia was rapid in all animals. Post‐induction apnoea was a feature in three of the 12 dogs. The blood propofol concentration‐time profile was best described by a bi‐exponential decline in two dogs in group 1 and in 3 dogs in group 2, and by a tri‐exponential decline in four dogs in group 1 and 3 dogs in group 2. The elimination half‐life was long in both groups (90.9 min and 75.2 min, respectively), the volume of distribution at steady state large (4889 and 4863 ml/kg) and the clearance rapid (58.6 and 56.3 ml/kg.min). There were no significant differences between the groups, thus indicating that maintenance of anaesthesia with halothane and nitrous oxide had no effect on the pharmacokinetics of propofol in the dog.