Premium
Circulatory and respiratory effects of the combination medetomidine‐ketamine in beagles
Author(s) -
SERTEYN D.,
COPPENS P.,
JONES R.,
VERSTEGEN J.,
PHILIPPART C.,
LAMY M.
Publication year - 1993
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1993.tb00164.x
Subject(s) - medetomidine , ketamine , anesthesia , respiratory system , cardiac output , heart rate , medicine , respiratory rate , vascular resistance , stroke volume , circulatory system , agonist , cardiology , pharmacology , blood pressure , hemodynamics , receptor
The cardiovascular and respiratory parameters of eight laboratory beagles were measured before and after the simultaneous injection of medetomidine (40 /igl kg bw) and ketamine (5 mg/bg bw). This combination produced a significant alteration in cardiovascular function. The heart rate, the stroke volume and cardiac output decreased while the systemic vascular resistance increased. These effects were attributed principally to the a 2 agonist compound combined with the moderate stimulatory effect of ketamine. The respiratory parameters were little affected by this protocol.