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Morantel tartrate release from a long‐acting intraregional device in cattle: pharmacokinetics and gastrointestinal distribution
Author(s) -
LANUSSE C. E.,
GASCON L. H.,
RANJAN S.,
PRICHARD R. K.
Publication year - 1992
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1992.tb00998.x
Subject(s) - pharmacokinetics , feces , bolus (digestion) , ileum , chemistry , horse , area under the curve , volume of distribution , zoology , high performance liquid chromatography , chromatography , pharmacology , medicine , biology , biochemistry , microbiology and biotechnology , paleontology
The pharmacokinetics and gastrointestinal distribution of ornately tart rate release from a sustained release trilaminate bolus in cattle were investigated over a 98‐day period post treatment. Six Holstein calves (125–150 kg) had permanent indwelling fistulae surgically inserted into the rumen, abomasum and terminal ileum. Samples of jugular blood, feces and ruminal, abomasal and ileal fluids were taken on days ‐3, 1, 4, 7, 10, 14 and weekly up to 98 days post‐bolus administration. Morantel tartrate concentrations were measured by HPLC after extraction and clean‐up. Morantel was not detected in plasma at any time after bolus administration. High concentrations of morantel tartrate were found in ruminal, abomasal and ileal fluids and feces over 98 days post‐treatment. The morantel peak concentration (C max ) was achieved at Day 1 post‐administration in each of these compartments. The steady‐state morantel concentration (C ss was achieved at approximately 10 days post‐treatment and maintained for 91–98 days post‐treatment in these gastrointestinal compartments. The morantel C max C ss , area under the zero (AUC) and first moment ( AUMC ) of the concentration‐time curve were significantly higher (P < 0.01) in feces than in other compartments. The in vivo drug release profile of this device has been determined. Steady‐state concentrations for from 91 to 98 days have been confirmed.