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Furosemide‐induced changes in plasma and blood volume of horses
Author(s) -
HINCHCLIFF K. W.,
McKEEVER K. H.,
MUIR W. W.
Publication year - 1991
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1991.tb00855.x
Subject(s) - furosemide , hematocrit , evans blue , chemistry , plasma volume , dilution , hemoglobin , plasma concentration , endocrinology , medicine , biochemistry , thermodynamics , physics
The effect of furosemide administration (1mg/kg body weight, i.v.) on plasma and blood volumes in 6 intact and 4 splenectomized horses was measured using Evans blue dye dilution, hematocrit, and hemoglobin and plasma total solids concentrations. Body weight decreased by 33.6±3.3 and 33.7±0.8g/kg 4h after furosemide administration to intact and splenectomized mares, respectively. Plasma volume, estimated by Evans blue dye dilution, was reduced by 8.3±3.3% (mean±SE) 4h after furosemide administration. The reduction in plasma volume was first detectable 5‐10 min after furosemide administration and was greatest 15‐30 min (13.0±0.8%) after dosing. This study demonstrates that furosemide produces significant and rapid reductions in plasma volume in horses. These decreases in plasma volume only partially resolve 4h after furosemide administration.