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Studies of meclofenamic acid and two metabolites in horses‐pharmacokinetics and effects on exercise tolerance
Author(s) -
M. JOHANSSON I.,
KALLINGS P.,
HAMMARLUNDUDENAES M.
Publication year - 1991
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1991.tb00832.x
Subject(s) - pharmacokinetics , volume of distribution , horse , chemistry , pharmacology , absorption (acoustics) , half life , anaerobic exercise , medicine , physiology , biology , paleontology , physics , acoustics
The pharmacokinetics and the effects on treadmill exercise of the antiinflammatory drug meclofenamic acid were studied in seven Standardbred horses after single intravenous and/or oral doses. The decline in plasma concentration after a single intravenous dose of meclofenamic acid (2.2 mg/kg b.wt) was described by a two‐compartment open model. The average elimination half‐life was 1.4 h, the apparent volume of distribution 0.14 1/kg and the plasma clearance 0.12 1/h kg. Absorption was the rate‐limiting step after oral administration. Non‐compartmental analysis showed a mean absorption time of 4.3 h. The pharmacokinetics of two metabolites of meclofenamic acid were also studied in two of the horses. The elimination half‐lives of the two metabolites were virtually the same in each horse (3.0 h and 3.4 h). The blood lactate response to exercise was significantly decreased after treatment with meclofenamic acid, indicating a lower utilization of the glycolytic (‘anaerobic’) energy contribution during exercise. Circulatory capacity was apparently unaffected with an unchanged heart rate response to exercise.