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Further studies on the antinociceptive activity and respiratory effects of buprenorphine in sheep
Author(s) -
WATERMAN A. E.,
LIVINGSTON A.,
AMIN A.
Publication year - 1991
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1991.tb00831.x
Subject(s) - buprenorphine , analgesic , nociception , respiratory rate , anesthesia , respiratory system , stimulus (psychology) , pharmacology , chemistry , medicine , opioid , heart rate , psychology , receptor , blood pressure , psychotherapist
The thermal and mechanical analgesic profile of buprenorphine at a dose rate of 1.5 μg/kg i.v. was investigated in five sheep. This dose produced significant analgesia for 40 min against the thermal stimulus, bin no mechanical antinocicep‐tion. A higher dose rate of 12 μg/kg also failed to produce anlinociceplion to a mechanical stimulus. In addition, the effect of the drug (6 μg/kg) on respiratory gas tensions was determined and no significant changes were observed.