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Phmacodynamics and pharmacokinetics of carprofen, a non‐steroidal anti‐inflammatory drug, in healthy cows and cows with Escherichia coli endotoxin‐induced mastitis
Author(s) -
LOHUIS J. A. C. M.,
WERVEN T.,
BRAND A.,
MIERT A. S. J. P. A. M.,
ROHDE E.,
LUDWIG B.,
HEIZMANN P.,
REHM W. F.
Publication year - 1991
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1991.tb00830.x
Subject(s) - carprofen , pharmacokinetics , mastitis , volume of distribution , medicine , pharmacodynamics , pharmacology , zoology , biology , pathology
The pharmacodynamics of carprofen and its pharmacokinetics in plasma and milk of healthy cows and cows with endotoxin‐induced mastitis were studied after a single intravenous dose of 0.7 mg/kg body weight. Carprofen was administered to five clinically healthy cows and to the same cows 3 weeks later, 2 h after intramammary infusion of endotoxin. Mastitis developed in all endotoxin‐infused quarters. The pharmacokinetic characteristics of carprofen in healthy cows were a small volume of distribution (0.09 I/kg), a relatively low systemic clearance (2.4 ml/h kg), and a long elimination half‐life (30.7 h). In the mastitic cows, systemic clearance (1.4 ml/h kg) was significantly lower (P < 0.01), and elimination half‐life (43.0 h) was significantly longer (P < 0.01) than in the normal animals. Concentrations of carprofen in milk from healthy quarters were below the limit of detection for the assay (0.022 (xg/ml). In milk from mastitic quarters, concentrations of carprofen increased up to 0.164 Hg/ml during the first 12 h after induction of mastitis, but were less than 0.022 ug/ml at 24 to 48 h. Compared with the untreated mastitic controls, carprofen treatment significantly reduced heart rate (P < 0.01), rectal temperature (P < 0.001), quarter swelling (P < 0.01) and other parameters measured. Local and systemic adverse reactions to carprofen were not observed.