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Plasma protein binding of nitroxynil in several species
Author(s) -
ALVINERIE M.,
FLOC'H R.,
GALTIER P.
Publication year - 1991
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1991.tb00819.x
Subject(s) - albumin , blood proteins , plasma protein binding , dialysis , plasma concentration , pharmacokinetics , chemistry , serum albumin , animal species , medicine , endocrinology , biology , biochemistry , pharmacology , zoology
The binding of nitroxynil to total plasma proteins of cows, sheep and rabbits was characterized using equilibrium dialysis. The data indicate clearly that nitroxynil was highly (97‐98%) bound to plasma protein of each animal. This linear binding would be due to the particular power exerted by serum albumin. The results are in good agreement with known pharmacokinetic properties of nitroxynil in domestic species.