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Disposition of human drug preparations in the horse. I. Rectally administered indomethacin
Author(s) -
DELBEKE F.T,
DEBACKERE M.,
VYNCKIER L.
Publication year - 1991
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1991.tb00816.x
Subject(s) - disposition , horse , pharmacology , drug , medicine , biology , psychology , social psychology , paleontology
A high‐performance liquid chromatographic method to measure urinary indomethacin levels is described. In 0.5 ml urine, 1 μg/ml of indomethacin could be detected. Alkaline hydrolysis of urine resulted in the decomposition of indomethacin. When two suppositories of Indocidr̀ corresponding to 200 mg indomethacin were administered rectally to four horses the drug was rapidly absorbed and remained detectable in urine from 1 to 12 h. The excretion rate peaked after 2‐3 h while the maximal concentration ranged from 18.5 to 80.6 μg/ml. Only 8 to 16% of the indomethacin dose was eliminated in urine after 12 h. A fraction of the dose was excreted as the glucuronide conjugate.