Premium
Pharmacokinetics of gentamicin after intravenous and subcutaneous injection in obese cats
Author(s) -
WRIGHT L. C.,
HORTON C. R.,
JERNIGAN A. D.,
WILSON R. C.,
CLARK C. H.
Publication year - 1991
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1991.tb00809.x
Subject(s) - cats , pharmacokinetics , volume of distribution , bioavailability , gentamicin sulfate , gentamicin , body weight , chemistry , subcutaneous injection , plasma concentration , zoology , anesthesia , medicine , endocrinology , pharmacology , antibiotics , biology , biochemistry
Six adult domestic shorthair obese cats were given 3‐mg/kg gentamicin sulfate by rapid i.v. and by s.c. injection in a cross‐over design. The plasma concentration time data were analyzed using statistical moment theory with no assumption of a specific compartmental model. Means ± SD for the half‐life, which was calculated from the terminal slope of the log concentration‐time curve, were 1.37 ± 0.24 and 1.24 ± 0.22 h following i.v. and s.c. injection, respectively. The apparent volume of distribution at steady state was 118.55 ± 19.83 ml/kg, and total body clearance was 1.07 ± 0.25 ml/kg/min. Bioavailability was 83.58 ± 14.83% after s.c. administration. The calculated s.c. dose in obese cats to produce an average steady‐state concentration of 4 μg/ml is 2.5 mg/kg every 8 h compared to 3 mg/kg in normal‐weight cats.