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Allometric analysis of doxycycline pharmacokinetic parameters
Author(s) -
RIOND J.L.,
RIVIERE J. E.
Publication year - 1990
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1990.tb00795.x
Subject(s) - doxycycline , pharmacokinetics , allometry , cats , body weight , pharmacology , chemistry , biology , veterinary medicine , medicine , antibiotics , biochemistry , ecology
Riond, J.‐L. & Riviere, J.E. Allometric analysis of doxycycline pharmacokinetic parameters. J. vet. Pharmacol. Therap. 13, 404–407. Doxycycline serum concentration‐time profiles and elimination half‐lives in several species were evaluated by allometric techniques. Doxycycline elimination half‐life increased with body weight. Interspecies scaling of total or free doxycycline serum concentration‐time profiles was possible by use of Dedrick plots with the exception of doxycycline total concentrations in cats. The observed difference in cats was attributed to more extensive binding to plasma proteins. Dr Jean‐Luc Riond, Pathophysiologisches Jnstitut, Universität Bern, Murtenstrasse 35, CH‐3010 Bern, Switzerland.