Premium
Chirality of the sulphoxide metabolites of fenbendazole and albendazole in sheep
Author(s) -
DELATOUR P.,
BENOIT E.,
GARNIER F.,
BESSE S.
Publication year - 1990
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1990.tb00790.x
Subject(s) - albendazole , fenbendazole , chirality (physics) , enantiomer , chemistry , pharmacology , pharmacokinetics , metabolite , plasma concentration , chromatography , anthelmintic , stereochemistry , biochemistry , medicine , veterinary medicine , surgery , chiral symmetry , physics , quantum mechanics , nambu–jona lasinio model , quark
Delatour, P., Benoit, E., Gamier, F. & Besse, S. Chirality of the sulphoxide metabolites of fenbendazole and albendazole in sheep. J. vet. Pharmacol. Therap. 13, 361–366. Two prochiral sulphide drugs, fenbendazole (FBZ) and albendazole (ABZ) were administered orally to sheep. Blood samples were analysed for parent drug and S‐oxidation metabolites and the chirality of the sulphoxide metabolites was determined. The plasma concentrations of the enantiomers of the sulphoxides were never a racemate. On the contrary, the ratios were greater than 1 as soon as the sulphoxide compounds could be detected in plasma. They subsequently increased linearly throughout the time course of the kinetics, reaching the level 86:14 after FBZ and 95:5 after ABZ treatment. The major enantiomer represented 74% and 86% of the total AUC of SO FBZ and SO ABZ, respectively. P. Delatour, Department of Biochemistry, National School of Veterinary Medicine of Lyon, BP 83, 69280‐Marcy I'Etoile, France.