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The effects of ambient temperature on amikacin pharmacokinetics in gopher tortoises
Author(s) -
CALIGIURI R.,
KOLLIAS G. V.,
JACOBSON E.,
McNAB B.,
CLARK C. H.,
WILSON R. C.
Publication year - 1990
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1990.tb00778.x
Subject(s) - amikacin , pharmacokinetics , volume of distribution , zoology , chemistry , regimen , pharmacology , medicine , biology , biochemistry , antibiotics
Caligiuri, R., Kollias, G.V., Jacobson, E., McNab, B., Clark, C.H. & Wilson, R.C. The effects of ambient temperature on amikacin pharmacokinetics in gopher tortoises. J. vet. Pharmacol. Therap. 13, 287–291. The pharmacokinetics of amikacin were compared in two groups of tortoises, one held at 20d̀C and the other at 30d̀C. The mean (± SD) residence time for amikacin in the 30d̀C tortoises was 22.67±0.50 h; significantly (P<0.05) less than those held at 20d̀C (41.83±3.23 h). There was no significant difference ( P >0.05) in the steady‐state volume of distribution (V d(ss) ) between the tortoises held at 30d̀C (0.241±0.520 l/kg) and those held at 20d̀C (0.221±0.019 l/kg). The clearance rate was faster ( P <0.05) in the warmer tortoises (10.65±2.42 ml/min/kg at 30d̀C compared to 5.27±0.152 ml/min/kg at 20d̀C). These data indicate that while the volume of distribution was approximately the same, amikacin remained in the colder tortoises longer because of its slower elimination. The oxygen consumption and metabolism were measured and found to be lower in the colder tortoises, almost by the same 2:1 ratio as clearance time (Cl) , mean residence time (MRT) , and area under the curve (AUC). The data derived from this limited study indicated that an appropriate therapeutic dosage regimen for amikacin in gopher tortoises at 30d̀C is 5 mg/kg given i.m. every 48 h. Dr Randy Caligiuri, University of Florida, College of Veterinary Medicine, Box J‐6 JHMHC, Gainesville, FL 32610, USA.