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Pharmacokinetics of sulfadimidine and its N 4 ‐acetyl metabolite in healthy and diseased rabbits infected with Pasteurella multocida
Author(s) -
YUAN ZHONGHUI,
FUNG KIFAI
Publication year - 1990
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1990.tb00768.x
Subject(s) - sulfadimidine , pharmacokinetics , metabolite , pasteurella multocida , chemistry , pharmacology , kidney , excretion , urine , volume of distribution , bolus (digestion) , gastrointestinal tract , active metabolite , medicine , biology , chromatography , biochemistry , bacteria , genetics
Yuan, Zhong‐Hui & Fung, Ki‐Fai. Pharmacokinetics of sulfadimidine and its N 4 ‐acetyl metabolite in healthy and diseased rabbits infected with Pasteurella multocida. J. vet. Pharmacol. Therap. 13, 192–197. The pharmacokinetics of sulfadimidine (SDM) and its N 4 ‐acetyl metabolite (N 4 SDM) were investigated after intravenous bolus injection of a single dose (200mg/kg) of SDM in normal and diseased New Zealand white rabbits. The apparent distribution volume at steady state, total body clearance and elimination half‐life of SDM in normal animals were 0.7±0.3l/kg, 0.57±0.24 l/kg/h and 1.6±1.3h, respectively. Of the administered dose, 62.1% was metabolized by N 4 ‐acetylation, and 12.7±1.1 and 2.8±1.8% of the dose was excreted as free drug by the kidney and gastrointestinal tract, respectively. The ‘apparent’ formation and elimination half‐lives of N 4 ‐SDM were 0.6±0.4 and 2.2±1.1h, respectively. The metabolite was eliminated mainly by excretion through the kidney. There was no significant effect of acute pasteurellosis on the pharmacokinetics of either SDM or N 4 SDM in rabbits. Yuan Zhong‐Hui, Laboratory of Veterinary Pharmacology, Department of Veterinary Medicine, South China Agricultural University, Guangzhou, China.