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The effect of phenylbutazone on the plasma disposition of penicillin G in the horse
Author(s) -
FIRTH E. C.,
NOUWS J. F. M.,
KLEIN W. R.,
DRIESSENS F.
Publication year - 1990
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1990.tb00766.x
Subject(s) - phenylbutazone , penicillin , procaine , horse , pharmacology , chemistry , medicine , antibiotics , biology , biochemistry , paleontology
Firth, E.C., Nouws, J.F.M., Klein, W.R. & Driessens, F. The effect of phenylbutazone on the plasma disposition of penicillin G in the horse. J. vet. Pharmacol. Therap. 13, 179–185. A pilot study in two ponies showed that the plasma concentrations of intramuscularly administered procaine penicillin were higher if phenylbutazone was administered concurrently. In two other trials, each involving five horses, intravenous sodium penicillin was administered with and without concurrent intravenously injected phenylbutazone, and procaine penicillin was injected intramuscularly with and without oral phenylbutazone. In both cases the plasma concentrations of penicillin were higher when phenylbutazone was given. The pharmacokinetic parameters indicated that the effect was probably due to a lower peripheral distribution because the penetration of penicillin into the tissues was greatly reduced. E. C. Firth, Veterinary Surgery and Companion Animal Health, Department of Clinical Sciences, Faculty of Veterinary Science, Massey University, Palmerston North, New Zealand.