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Absorption of two trimethoprim/sulphonamide combinations from the uterus of pony mares
Author(s) -
BOYD E. H.,
ALLEN W. E.
Publication year - 1989
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1989.tb00695.x
Subject(s) - trimethoprim , pony , sulfadoxine , ovulation , medicine , pregnancy , pharmacology , antibiotics , pyrimethamine , biology , microbiology and biotechnology , immunology , malaria , genetics , hormone , plasmodium falciparum
Plasma drug concentrations were measured after two commercially available potentiated sulphonamides, trimethoprim and sulfadoxine and trimethoprim and sulphadiazine, were infused daily for 2 and 3 days, respectively, into the uteri of pony mares which had been mated before ovulation. Intravenous administration of trimethoprim and sulfadoxine allowed uterine absorption of trimethoprim (23–43%) and sulfadoxine (29–34%) to be calculated. After intrauterine administration trimethoprim and sulphadiazine were detected in the milk of a lactating mare. In order to maintain plasma concentrations likely to be required for clinical efficacy of both drugs they should be administered every 12 h. However, infusions of both preparations caused endometrial inflammation as assessed by cytological and histological examination and this may have been responsible for the low pregnancy rate.