Premium
Effect of flunixin meglumine on prostaglandin F 2α synthesis and metabolism in the pig
Author(s) -
ODENSVIK K.,
CORT N.,
BASU S.,
KINDAHL H.
Publication year - 1989
Publication title -
journal of veterinary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.527
H-Index - 60
eISSN - 1365-2885
pISSN - 0140-7783
DOI - 10.1111/j.1365-2885.1989.tb00676.x
Subject(s) - chemistry , prostaglandin , pharmacology , in vivo , metabolite , metabolism , drug metabolism , drug , microsome , prostaglandin e2 , prostaglandin e , in vitro , endocrinology , biochemistry , medicine , biology , microbiology and biotechnology
The effect of flunixin meglumine on prostaglandin synthesis and metabolism was evaluated in the pig in vivo. It was found that the prostaglandin metabolite, 15‐ketodihydro‐PGF 2α , was decreased in the peripheral circulation within 20 min of injection of the drug. In therapeutic doses in the pig the drug had no effect on the metabolism of PGF 2α . Flunixin was compared with some other non‐steroidal anti‐inflammatory drugs in an in vitro test system utilizing sheep vesicular gland microsomes. It was concluded that this drug is a potent inhibitor of prostaglandin synthesis.